| 斯氏线虫-致病杆菌共生体侵染昆虫的生物标志物 |
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| 引用本文：张媛,王芳,赵紫华.斯氏线虫-致病杆菌共生体侵染昆虫的生物标志物.植物保护学报,2023,50(5):1227-1236 |
| DOI：10.13802/j.cnki.zwbhxb.2023.2022074 |
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| 中文摘要:昆虫病原线虫是一类专性侵染和寄生昆虫的病原线虫，是非常重要的生防资源。斯氏线虫属Steinernema和致病杆菌属Xenorhabdus通过形成共生体在侵染昆虫过程中共同完成生活史，其中致病杆菌释放效应物质引发昆虫败血症是其重要机制。该文对斯氏线虫-致病杆菌共生体的侵染策略和在侵染过程中产生的免疫调节因子、释放的毒素蛋白和活性代谢物进行概述，其中，苯乙酰胺作为免疫抑制因子促进自身定殖，脂多糖作为内毒素引起寄主血细胞裂解，Tc毒素蛋白作为外毒素导致寄主中肠上皮细胞溶解，活性代谢产物如xenematides、fabclavine和PAX肽等具有抑菌、诱导细胞凋亡等活性。而斯氏线虫本身也能够产生表皮/分泌蛋白来抑制寄主免疫，与共生菌协同致死寄主。因此，通过对斯氏线虫-致病杆菌共生体产生的致病物质进行汇总分析，为研究昆虫病原线虫致病机制提供理论参考，同时也为新型绿色杀虫剂的开发和应用提供证据支持。 |
| 中文关键词:昆虫病原线虫 斯氏线虫 致病杆菌 侵染策略 生物标志物 |
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| Biomarkers of insect septicemia caused by Steinernema-Xenorhabdus symbionts |
| Author Name | Affiliation | E-mail | | Zhang Yuan | Key Laboratory of Surveillance and Management for Plant Quarantine Pests of Ministry of Agriculture and Rural Affairs, College of Plant Protection, China Agricultural University, Beijing 100193, China | | | Wang Fang | Institute of Plant Protection, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan 750002, Ningxia Hui Autonomous Region, China | | | Zhao Zihua | Key Laboratory of Surveillance and Management for Plant Quarantine Pests of Ministry of Agriculture and Rural Affairs, College of Plant Protection, China Agricultural University, Beijing 100193, China | zhzhao@cau.edu.cn |
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| Abstract:Entomopathogenic nematodes (EPNs), which are obligate parasitic nematodes that infect a wide range of insects, are a valuable resource for biocontrol. During the process of infecting a host insect, the Steinernema-Xenorhabdus symbionts releases various pathogenic factors to complete their life cycle. In this paper, the pathogenic strategies employed by Steinernema spp. and Xenorhabdus spp. were reviewed. This includes utilizing phenylethylamides as immunosuppressive factors to facilitate colonization, lipopolysaccharide (LPS) as an endotoxin to cause host blood cell lysis, Tc proteins as exotoxins to kill host insects, and the production of special metabolites (e.g. fabclavine, PAX peptides, and other antibiotics) that have bacteriostatic and apoptosis-inducing activities. Additionally, some epidermal/ secretory proteins can inhibit the host's immune system, work together with the symbiotic bacteria to kill the host, and cause a series of changes in the host insect's physiology and metabolism. Therefore, this review of the biochemical metabolism caused by Steinernema-Xenorhabdus symbionts can serve as both a theoretical guide for exploring the septicemia mechanism of EPN infestations and as evidence to support the creation of novel, environmentally friendly insecticides. |
| keywords:entomopathogenic nematodes Steinernema Xenorhabdus infestation strategies biomarker |
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