表皮蛋白介导害虫抗药性机制的研究进展 Click here to download the full text Citation：李双龙,刘雨茜,李玉婷,杨雪清.表皮蛋白介导害虫抗药性机制的研究进展.Journal of Plant Protection,2026,53(2):301-310 Hits: Download times: Author Name Affiliation E-mail Li Shuanglong  Key Laboratory of Major Agricultural Invasive Species Monitoring and Control in Shenyang City Key Laboratory of Economic and Applied Entomology, Liaoning Provincial Department of Education College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, Liaoning Province, China    Liu Yuxi  Key Laboratory of Major Agricultural Invasive Species Monitoring and Control in Shenyang City Key Laboratory of Economic and Applied Entomology, Liaoning Provincial Department of Education College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, Liaoning Province, China    Li Yuting  Key Laboratory of Major Agricultural Invasive Species Monitoring and Control in Shenyang City Key Laboratory of Economic and Applied Entomology, Liaoning Provincial Department of Education College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, Liaoning Province, China  yutingli2017@syau.edu.cn  Yang Xueqing  Key Laboratory of Major Agricultural Invasive Species Monitoring and Control in Shenyang City Key Laboratory of Economic and Applied Entomology, Liaoning Provincial Department of Education College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, Liaoning Province, China  xqyang@syau.edu.cn  中文摘要:害虫对杀虫剂的抗性演化已成为制约全球农业可持续发展的关键因素。相较于靶标抗性和代谢抗性，表皮穿透抗性是昆虫对具有触杀作用机制杀虫剂的先期抗性策略，其主要是降低杀虫剂穿透昆虫外表屏障及到达靶标的效率，一方面减少杀虫剂的渗入量，另一方面延长杀虫剂在体内的解毒时间，从而增强抗性效果，常与其他抗性机制协同发挥作用。该文综述表皮介导害虫抗药性机制的最新研究进展，重点关注表皮穿透抗性形成的分子基础、关键调控网络及其进化特征，并对未来研究进行展望，以期为害虫抗药性治理策略制订提供新思路。 中文关键词:表皮蛋白  穿透抗性  抗性机制  协同作用  抗性治理   Research progress on the mechanism of insect resistance mediated by cuticular proteins Author Name Affiliation E-mail Li Shuanglong  Key Laboratory of Major Agricultural Invasive Species Monitoring and Control in Shenyang City Key Laboratory of Economic and Applied Entomology, Liaoning Provincial Department of Education College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, Liaoning Province, China    Liu Yuxi  Key Laboratory of Major Agricultural Invasive Species Monitoring and Control in Shenyang City Key Laboratory of Economic and Applied Entomology, Liaoning Provincial Department of Education College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, Liaoning Province, China    Li Yuting  Key Laboratory of Major Agricultural Invasive Species Monitoring and Control in Shenyang City Key Laboratory of Economic and Applied Entomology, Liaoning Provincial Department of Education College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, Liaoning Province, China  yutingli2017@syau.edu.cn  Yang Xueqing  Key Laboratory of Major Agricultural Invasive Species Monitoring and Control in Shenyang City Key Laboratory of Economic and Applied Entomology, Liaoning Provincial Department of Education College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, Liaoning Province, China  xqyang@syau.edu.cn  Abstract:The evolution of insecticide resistance in pests has become a critical challenge restricting the sustainable development of global agriculture. Compared with target-site resistance and metabolic resistance, cuticular penetration resistance is an early-stage resistance strategy adopted by insects to defend against insecticides with contact action. It primarily reduces the efficiency of insecticide penetration through the insect's outer barrier and its delivery to the target site. On one hand, it decreases the amount of insecticide that penetrates; on the other hand, it prolongs the detoxification time of the insecticide within the body, thereby enhancing the resistance effect. This mechanism often synergizes with other resistance mechanisms. This systematic review summarizes the latest research progress on the cuticle-mediated mechanisms of insecticide resistance in pests. It focuses on the molecular basis underlying the formation of cuticular penetration resistance, the key regulatory networks, and its evolutionary characteristics. Future perspectives are also discussed, aiming to provide new insights for pest resistance management strategies. keywords:cuticular protein  penetration resistance  resistance mechanism  synergistic effect  resistance management View Full Text  View/Add Comment  Download reader

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