昆虫γ-氨基丁酸转运蛋白的研究进展 Click here to download the full text Citation：张一弛,朱彬洲,鲍建,汪莹,唐涛,赵春青.昆虫γ-氨基丁酸转运蛋白的研究进展.Journal of Plant Protection,2026,53(4):859-868 Hits: Download times: Author Name Affiliation E-mail Zhang Yichi  College of Plant Protection, Nanjing Agricultural University, Nanjing 211800, Jiangsu Province, China    Zhu Binzhou  Shandong Binnong Technology Co., Ltd., Binzhou 256600, Shandong Province, China    Bao Jian  College of Plant Protection, Nanjing Agricultural University, Nanjing 211800, Jiangsu Province, China    Wang Ying  College of Plant Protection, Nanjing Agricultural University, Nanjing 211800, Jiangsu Province, China    Tang Tao  Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha 410125, Hunan Province, China    Zhao Chunqing  College of Plant Protection, Nanjing Agricultural University, Nanjing 211800, Jiangsu Province, China  zcq@njau.edu.cn  中文摘要:γ-氨基丁酸（gamma-aminobutyric acid，GABA）是昆虫神经系统中主要的一种抑制性神经递质，其通过与GABA受体结合来传递细胞间抑制性神经信号。而GABA转运蛋白（GABA transporter，GAT）对GABA起着重要的调控作用。昆虫中GAT包括质膜GAT（plasma membrane GABA transporter，pmGAT）和囊泡GAT（vesicular GABA transporter，vGAT），这两种类型的GAT广泛分布于昆虫中枢神经系统中。pmGAT位于细胞质膜上，负责再摄取突触间隙的GABA；vGAT位于前突触内囊泡膜上，负责将胞质内GABA贮存于囊泡中以备释放。该文综述了近年来昆虫中pmGAT和vGAT的研究进展，重点围绕其分子结构、系统进化、空间分布、时空表达特征以及生理功能等方面进行阐述，为深入了解GABA能神经传递的分子基础及开发新型害虫防控靶标提供参考。 中文关键词:昆虫  γ-氨基丁酸  转运蛋白  质膜GAT  囊泡GAT   Research progress on γ-aminobutyric acid transporters in insect Author Name Affiliation E-mail Zhang Yichi  College of Plant Protection, Nanjing Agricultural University, Nanjing 211800, Jiangsu Province, China    Zhu Binzhou  Shandong Binnong Technology Co., Ltd., Binzhou 256600, Shandong Province, China    Bao Jian  College of Plant Protection, Nanjing Agricultural University, Nanjing 211800, Jiangsu Province, China    Wang Ying  College of Plant Protection, Nanjing Agricultural University, Nanjing 211800, Jiangsu Province, China    Tang Tao  Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha 410125, Hunan Province, China    Zhao Chunqing  College of Plant Protection, Nanjing Agricultural University, Nanjing 211800, Jiangsu Province, China  zcq@njau.edu.cn  Abstract:Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the insect nervous system, mediating inhibitory synaptic transmission through binding to GABA receptors. GABA transporters (GATs) play essential roles in regulating GABAergic neurotransmission. In insects, GATs include plasma membrane GABA transporters (pmGATs) and vesicular GABA transporters (vGATs), of which are widely distributed in the central nervous system. pmGATs are located to the plasma membrane and are responsible for the reuptake of GABA from the synaptic cleft, whereas vGATs are located to synaptic vesicle membranes within presynaptic terminals and mediate the uptake of cytoplasmic GABA into synaptic vesicles for subsequent release. This review summarizes recent advances in the study of insect pmGATs and vGATs, with emphasis on their molecular structures, phylogenetic relationships, spatial distribution, spatiotemporal expression patterns, and physiological functions. It aims to provide a reference for understanding the molecular basis of GABAergic neurotransmission and for identifying potential molecular targets for the development of novel pest control strategies. keywords:insect  γ-aminobutyric acid  transporter  plasma membrane GABA transporter  vesicular GABA transporter View Full Text  View/Add Comment  Download reader

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