小菜蛾对Bt Cry1Ac杀虫蛋白抗性的遗传与信号调控机制 Click here to download the full text Citation：龚莉君,康师,钟杨,郭兆将.小菜蛾对Bt Cry1Ac杀虫蛋白抗性的遗传与信号调控机制.Journal of Plant Protection,2026,53(4):869-880 Hits: Download times: Author Name Affiliation E-mail Gong Lijun  School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, Hubei Province, China    Kang Shi  College of Life Sciences, Hebei University, Baoding 071002, Hebei Province, China    Zhong Yang  School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, Hubei Province, China  hubeispider@aliyun.com  Guo Zhaojiang  State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China  guozhaojiang@caas.cn  中文摘要:十字花科蔬菜是我国最重要的蔬菜类群之一，不仅是“菜篮子”工程的核心品类，更是种业振兴、乡村振兴和功能农业的重要抓手。小菜蛾Plutella xylostella是十字花科蔬菜的重大害虫之一，每年给农业造成巨额经济损失。苏云金芽胞杆菌Bacillus thuringiensis（Bt）能产生多种杀虫蛋白（如Cry1Ac），因其杀虫特性高效特异和环境友好等特点，在小菜蛾防治中发挥着重要作用。然而，小菜蛾已对Bt Cry1Ac杀虫蛋白产生抗性，这严重阻碍了Bt的实际应用效果。该文综述了小菜蛾对Bt Cry1Ac杀虫蛋白的抗性机制，重点阐述了中肠受体变异及信号通路改变为主导的抗性进化途径。此外，展望了未来研究方向，提出应综合运用现代遗传学、分子生物学及多组学技术进一步揭示其抗性分子机制。 中文关键词:小菜蛾  苏云金芽胞杆菌  Cry杀虫蛋白  抗性机制  信号途径   Genetic and signaling regulatory mechanisms underlying resistance to the Bt Cry1Ac toxin in the diamondback moth Plutella xylostella Author Name Affiliation E-mail Gong Lijun  School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, Hubei Province, China    Kang Shi  College of Life Sciences, Hebei University, Baoding 071002, Hebei Province, China    Zhong Yang  School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, Hubei Province, China  hubeispider@aliyun.com  Guo Zhaojiang  State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China  guozhaojiang@caas.cn  Abstract:Cruciferous vegetables are among the most important vegetable crops in China. They are not only a core component of the national vegetable supply system but also play a crucial role in seed industry revitalization, rural development, and functional agriculture. The diamondback moth Plutella xylostella is a major pest of cruciferous vegetables and causes substantial economic losses to agricultural production each year. Bacillus thuringiensis (Bt) produces a variety of insecticidal proteins, including Cry1Ac, which have been widely used for the control of P. xylostella because of their high efficacy, target specificity, and environmental safety. However, the evolution of resistance to the Bt Cry1Ac toxin in P. xylostella has greatly reduced the effectiveness of Bt-based pest control. This review summarizes the resistance mechanisms of P. xylostella to Bt Cry1Ac toxin, with particular emphasis on resistance evolution mediated by alterations in midgut receptors and signaling pathways. Future research directions are also discussed, highlighting the need to integrate modern genetics, molecular biology, and multi-omics approaches to further elucidate the molecular mechanisms underlying Bt resistance. keywords:Plutella xylostella  Bacillus thuringiensis  Cry toxin  resistance mechanism  signaling pathway View Full Text  View/Add Comment  Download reader

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